Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer
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چکیده
منابع مشابه
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents. The efficacy of tamoxifen, raloxifene, and exemestane as preventive therapy against estrogen-receptor (ER)-positive breast cancer is well established for women at inc...
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ABSTRACT Background: The aims of this study were to assay the activity of adenosine deaminase (ADA) in estrogen receptor positive (MCF-7) and negative (MDA-MB468) breast cancer cell lines. Methods: MDA-MB468 and MCF-7 breast cancer cell lines were cultured in complete medium, striped serum with and without 0.0 1~-LM diethylstilbestrol (DES), complete medium in the presence and absence of 111M ...
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Triple negative breast cancer is a highly aggressive and invasive breast cancer that is difficult to diagnose and treat, since it lacks estrogen, progesterone, and human epidermal growth factor receptors. To treat triple negative breast cancer as well as other forms of breast cancer, researchers are studying high dose estrogen therapy as a potential chemotherapeutic treatment. Clinical trials w...
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Endocrine therapies for breast cancer that target the estrogen receptor (ER) are ineffective in the 25%-30% of cases that are ER negative (ER-). Androgen receptor (AR) is expressed in 60%-70% of breast tumors, independent of ER status. How androgens and AR regulate breast cancer growth remains largely unknown. We find that AR is enriched in ER- breast tumors that overexpress HER2. Through analy...
متن کاملCASPASE DEPENDENT APOPTOSIS INDUCED BY CLADRIBINE IN THE ESTROGEN RECEPTOR NEGATIVE BREAST CANCER CELL LINE, MDA-MB468
The purpose of the present study is to investigate the cytotoxicity/apoptotic effect of 2-chloro-2′-deoxyadenosine, cladribine, (2-CdA) in the human breast cancer cell line, MDA-MB468 (estrogen receptor negative, ER−). MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] assay, annexin V-Fluorescein/PI and Hoechst 33258 staining were used to detect cytotoxicity and cell apopto...
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ژورنال
عنوان ژورنال: Current Breast Cancer Reports
سال: 2014
ISSN: 1943-4588,1943-4596
DOI: 10.1007/s12609-014-0144-1